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This abstract is assigned to session Free Paper Session I: Diagnosis and Monitoring
Presentation preference Oral
review resultOral
TitleClinicopathological, immunohistochemistry and molecular biologic correlation in uveitis & scleritis
Accept poster if oral is not possible ?Yes
PurposeTo describe clinicopathological,immunohistochemistry and molecular biologic correlation in end stage uveitis and scleritis
MethodsHistopathology, immunohistochemistry and molecular biologic study of eviscerated or enucleated tissues of end-stage uveitis and scleritis in 18 cases over a period of 10 years
ResultsIn Vogt-Koyanagi-Harada syndrome (1 case) and Sympathetic Ophthalmia(9 cases), predominant T-cell infiltration of the choroid was noted. In 3 cases of tubercular panuveitis, mycobacterial tuberculosis(MTB) genome was detected by nested and real-time PCR. Acid-fast bacilli were seen within retinal pigment epithelium in 1 case of TB panuveitis which was clinically diagnosed as choroidal melanoma. Predominant T cell involvement was seen in Eales' disease. Nested PCR was positive in 2 cases of Eales’ disease. In addition, real-time PCR was positive in 1 of the Eales’ disease case. Lymphocytic infiltration was present in a viral retinitis case. In 1 case of scleritis, Mycobacterial tubercular genome was detected and in the other case, giant nodular posterior scleral inflammation was noted.
ConclusionClinicopathological, immunohistochemistry and molecular biologic study can provide important insight into the pathogenesis of end-stage uveitis and scleritis
Conflict of interestNo
Author 1
Last nameBISWAS
Initials of first name(s)J
Department Uveitis and Ocular Pathology Sankara Nethralaya
CityChennai
CountryIndia
Author 2
Last nameDas
Initials of first name(s)D
Department Uveitis and Ocular Pathology Sankara Deva Nethralaya
City Guwahati
CountryIndia
Author 3
Last nameJanani
Initials of first name(s)M K
DepartmentMolecular biology, Vision Research Foundation
CityChennai ,
CountryIndia
Author 4
Last name Patnaik
Initials of first name(s)G
Department Uveitis, Sankara Nethralaya
CityChennai ,
CountryIndia
Author 5
Last nameKrishnakumar
Initials of first name(s)S
DepartmentOcular Pathology
CityChennai ,
CountryIndia