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This abstract is assigned to session Free Paper Session IV: Infectious Disease II
Presentation preference Oral
review resultOral
TitleVirus-associated anterior uveitis and secondary glaucoma
Accept poster if oral is not possible ?Yes
PurposeCompare clinical characteristics and analyze glaucoma development/surgery requirements in patients with different virus-associated anterior uveitis (VAU).
MethodsStudy of 270 patients with VAU confirmed by positive Goldmann-Witmer-coefficients(GWC) for cytomegalovirus(CMV), herpes simplex virus(HSV), varicella-zoster virus(VZV), rubella virus(RV), & multiple-viruses(MV).Demographic constitution, clinical findings, glaucoma development, and surgeries were recorded.
ResultsGWC analysis showed positive results for CMV(21%), HSV(29%), VZV(17%), RV(29%), and MV(5%). CMV and RV AU occur predominantly in younger/male patients, while VZV and HSV AU appeared in elderly/females. Unilateral involvement was typical for almost all viruses(76-98%), but 24% of VZV also showed bilateral manifestation. Course of disease was mainly acute for CMV(96%), while chronic disease was observed in RV(84%) and in HSV(68%). Differences like iris synechia, vitreous haze, and macular edema were noted. In total, 19% showed glaucomatous damage and 10% needed glaucoma surgery. Minimal-invasive glaucoma surgery resulted in a reliable IOP reduction in short-term period. In 37% first surgical intervention failed, and a follow-up surgery was required.
ConclusionDifferent virus entities show common clinical findings. To establish an appropriate treatment, it is important to confirm the diagnosis by GWC. Otherwise, development of secondary glaucoma as a serious complication of uveitis is inevitable. It is crucial to choose distinctive therapeutic approaches like appropriate surgical interventions to avoid vision-threatening complications.
Conflict of interestNo
Author 1
Last namePOHLMANN
Initials of first name(s)D
DepartmentOphthalmology, Charité
CityBerlin
CountryGermany
Author 2
Last namePahlitzsch
Initials of first name(s)M
DepartmentCharité
CityBerlin
CountryGermany
Author 3
Last nameWinterhalter
Initials of first name(s)S
DepartmentCharité
CityBerlin
CountryGermany
Author 4
Last namePleyer
Initials of first name(s)U
DepartmentCharité
CityBerlin
CountryGermany