| Presentation preference | Oral presentation |
| Title | Idiopathic MFC and PIC: an evaluation in pregnancy |
| Purpose | To evaluate the clinical course of idiopathic multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC) and the efficacy and safety of treatment options during pregnancy. |
| Methods | Patients with MFC or PIC and a pregnancy in 2011–2019 were enrolled. For the most recent pregnancy, data on best corrected visual acuity (BCVA) before and after pregnancy, relapse rate in pregnancy and postpartum period and maternal and neonatal outcomes were collected. Treatment regimens consisted of a wait-and-see regime and an immunosuppressive treatment with systemic corticosteroids and/or azathioprine, both combined with intravitreal anti-VEGF injections when indicated. |
| Results | Sixteen women (26 affected eyes) were included. Median Snellen BCVA was 20/19 before pregnancy and 20/18 after delivery. In nine pregnancies an immunosuppressive treatment regime was carried out. Fourteen intravitreal anti-VEGF injections were given in six pregnancies. The relapse rate during pregnancy was 44% and in the postpartum period 31%. Maternal and fetal complications occurred in 31% and 13% of the pregnancies, respectively. Fifteen healthy children were born and one pregnancy ended in a stillbirth in a patient with a complicated obstetrical history. One patient treated with azathioprine developed intrahepatic cholestasis of pregnancy (ICP). |
| Conclusion | Among pregnant women with MFC and PIC, BCVA remained stable despite a relapse rate of 44% in pregnancy. No major maternal and fetal complications occurred in treated pregnant patients, though one patient developed ICP. |
| Conflict of interest | No |
Authors 1
| Last name | OSSEWAARDE-VAN NOREL |
| Initials of first name(s) | J |
| Department | University Medical Center Utrecht |
| City | Utrecht |
| Country | Netherlands |
Authors 2
| Last name | de Groot |
| Initials of first name(s) | EL |
| Department | UMCU |
| City | Utrecht |
| Country | Netherlands |
Authors 3
| Last name | Bloemenkamp |
| Initials of first name(s) | KWM |
| Department | UMCU |
| City | Utrecht |
| Country | Netherlands |
Authors 4
| Last name | van Huet |
| Initials of first name(s) | RAC |
| Department | Radboud UMC |
| City | Nijmegen |
| Country | Netherlands |
Authors 5
| Last name | de Boer |
| Initials of first name(s) | JH |
| Department | UMCU |
| City | Utrecht |
| Country | Netherlands |
