MYOPIC CHOROIDAL NEOVASCULARIZATION AS THE PREMONITORY SIGN OF PUNCTATE INNER CHOROIDOPATHY
Purpose
To describe five young patients, who presented with myopic choroidal neovascularization (mCNV) as the preliminary sign of punctate inner choroidopathy (PIC).
Methods
Retrospective review
Results
: Five myopic patients (3 females, 2 males) with a mean age of 26.4±8.20 years, presented with mCNV in one eye. Mean refractive error was -9.33±3.56 diopters. Mean time interval between mCNV development and appearance of PIC was 12.85±8.46 months. PIC developed in the ipsilateral eye in all 5 patients. Blurred vision was the presenting symptom of PIC in 4 patients. In one patient, PIC was disclosed incidentally.
Mean LogMAR best-corrected visual acuity (BCVA) at presentation was 0.49±0.50 and it was 0.11±0.12 at the most recent visit just before the development of PIC. At PIC diagnosis, mean LogMAR BCVA was 0.12±0.11 and it was 0.07±0.05 at the last follow-up. mCNV was treated with intravitreal anti-VEGF therapy in all cases. Corticosteroids were instituted for the treatment of PIC in all patients, a steroid-sparing agent was additionally used in three patients and biologic therapy (adalimumab) was used in two patients. Mean follow-up time was 28.2±13.87 months.
Conclusion
: mCNV may be the first sign of PIC presenting well before the development of PIC lesions. Eyes with high myopia have an occult chronic pro-inflammatory state. Close follow-up and a high index of suspicion is essential for the timely diagnosis and management of this potentially sight-threatening condition.
Conflict of interest
No
Authors 1
Last name
CORREDORES DIEB
Initials of first name(s)
J
Department
Ophthalmology - Hadassah Medical Center
City
JERUSALEM
Country
Israel
Authors 2
Last name
Jaouni
Initials of first name(s)
T
Department
Ophthalmology - Hadassah Medical Center
City
JERUSALEM
Country
Israel
Authors 3
Last name
Amer
Initials of first name(s)
R
Department
Ophthalmology - Hadassah Medical Center
City
JERUSALEM
Country
Israel
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