Epidemiology, Treatment, and Outcome of Juvenile Idiopathic Arthritis-associated Uveitis: a Multi-institutional Study in Taiwan
Purpose
To evaluate the epidemiological characteristics and clinical outcomes of patients with Juvenile Idiopathic Arthritis (JIA)-associated uveitis in Taiwan. The study aims to provide valuable insights to understand the specific pattern of JIA in Taiwan, and improve patient outcomes, and identify potential risk factors associated with poor prognosis
Methods
In this retrospective, multi-institutional study, we analyzed the medical records of patients diagnosed with JIA-associated uveitis between 2001 and 2019 from the Chang Gung Research database, which covers approximately 10% of total medical service volume in Taiwan. Data on demographics, clinical features, treatment regimens, and follow-up outcomes were collected and analyzed.
Results
A total of 722 JIA patients and 44 patients (6%) with JIA-associated uveitis were identified in the study period. The mean age at diagnosis for JIA-uveitis was 9.6±4.2 years, a female-to-male ratio of 43%:57%. Anterior uveitis accounted for 88.6%, while panuveitis 9.1% and posterior uveitis 2.3%. 57.9% uveitis patients recurred in 6 months after cessation of the DMARDs. 31.6% of female uveitis patients and 12.0% of male uveitis patients had eye complications. Age less than 6 years showed a more progressive disease course and worse visual prognosis than age more than 6.
Conclusion
Compared to other nations, Low prevalence of uveitis in JIA (6.1%), more male than female (6:4), and relative late onset of JIA (9.6 y/o) can be found. Further research on risk stratification and individualized treatment strategies is warranted to improve patient outcomes in this population.
Conflict of interest
No
Authors 1
Last name
HWANG
Initials of first name(s)
YS
Department
Ophthalmology
City
Linkou
Country
Taiwan
Authors 2
Last name
Wu
Initials of first name(s)
PY
Department
Ophthalmology
City
LInkou
Country
Taiwan
Authors 3
Last name
Kang
Initials of first name(s)
EYC
Department
Ophthalmology
City
Linkou
Country
Taiwan
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