Clinicopathological, immunohistochemistry and molecular biologic correlation in uveitis & scleritis
Purpose
To describe clinicopathological,immunohistochemistry and molecular biologic correlation in end stage uveitis and scleritis
Methods
Histopathology, immunohistochemistry and molecular biologic study of eviscerated or enucleated tissues of end-stage uveitis and scleritis in 18 cases over a period of 10 years
Results
In Vogt-Koyanagi-Harada syndrome (1 case) and Sympathetic Ophthalmia(9 cases), predominant T-cell infiltration of the choroid was noted. In 3 cases of tubercular panuveitis, mycobacterial tuberculosis(MTB) genome was detected by nested and real-time PCR. Acid-fast bacilli were seen within retinal pigment epithelium in 1 case of TB panuveitis which was clinically diagnosed as choroidal melanoma. Predominant T cell involvement was seen in Eales' disease. Nested PCR was positive in 2 cases of Eales’ disease. In addition, real-time PCR was positive in 1 of the Eales’ disease case. Lymphocytic infiltration was present in a viral retinitis case. In 1 case of scleritis, Mycobacterial tubercular genome was detected and in the other case, giant nodular posterior scleral inflammation was noted.
Conclusion
Clinicopathological, immunohistochemistry and molecular biologic study can provide important insight into the pathogenesis of end-stage uveitis and scleritis
Conflict of interest
No
Author 1
Last name
BISWAS
Initials of first name(s)
J
Department
Uveitis and Ocular Pathology Sankara Nethralaya
City
Chennai
Country
India
Author 2
Last name
Das
Initials of first name(s)
D
Department
Uveitis and Ocular Pathology Sankara Deva Nethralaya
City
Guwahati
Country
India
Author 3
Last name
Janani
Initials of first name(s)
M K
Department
Molecular biology, Vision Research Foundation
City
Chennai ,
Country
India
Author 4
Last name
Patnaik
Initials of first name(s)
G
Department
Uveitis, Sankara Nethralaya
City
Chennai ,
Country
India
Author 5
Last name
Krishnakumar
Initials of first name(s)
S
Department
Ocular Pathology
City
Chennai ,
Country
India
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