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TitleAlterations in choriocapillaris flow pattern in patients with active presumed tubercular serpiginous like choroiditis
PurposeTo report changes in choriocapillaris flow deficits (CCFD%) in patients diagnosed with active tubercular serpiginous like choroiditis (TB-SLC) using swept source optical coherence tomography angiography (SS-OCTA
Methods: Patients with active TB-SLC and age matched healthy controls underwent SS-OCTA. Choriocapillaris slab with 20-micron thickness beneath RPE fit line from the structural OCT with the corresponding angioplex slab was segmented. These images were analysed using previously validated image binarization algorithm to calculate flow deficit in CC slab.
Results: Twenty-six patients (34 eyes) with TB-SLC and 34 healthy controls (34 eyes) were included, of which 21 (81%) with TB-SLC and 6 (18 %) of controls were males. . There was a statistically significant difference in the CCFD between TB - SLC patients (23.64 ± 2.35%) and controls (33.40 ± 7.43%; p < 0.001). A moderate negative correlation was noted between CCFD and visual acuity at presentation (r= -0.46, P=0.006). Linear regression showed an increase in CCFD to be the independent predictor for reduced visual acuity (RR= 0.03, 95% CI: 0.01 to 0.05, p=0.006
Conclusion SS-OCTA is useful in CCFD in patients with TB-SLC .These deficits increase with active cases, the CCFD can be used a predictor of visual outcome in patients with TB-SLC.
Conflict of interestNo
Authors 1
Last nameBISWAS
Initials of first name(s)J
DepartmentUveitis and ocular pathology
Authors 2
Last name Magesan
Initials of first name(s)K
Authors 3
Last nameVerma
Initials of first name(s)A
Department Vitreoretina