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TitleAcute zonal occult outer retinopathy (AZOOR) – Largest series in south India.
PurposeAcute zonal occult outer retinopathy (AZOOR) is a clinical entity characterised by acute loss of outer retinal function with minimal or no visible fundal changes, associated with visual field loss, characteristic optical coherence tomography (OCT), Fundus autofluorescence (FAF) and electroretinogram (ERG) abnormalities. There are over 100 cases worldwide, mainly centring on Caucasians. Knowledge is limited to few studies and isolated case reports in Asians. We evaluated the clinical profile of patients with AZOOR in south India.
MethodsAn observational case series of six patients with clinical features and multimodal retinal imaging suggestive of AZOOR was carried out over a period of one year presenting to a tertiary eye care referring center in south India. We analysed the visual potential and correlated with different multimodal imaging.
ResultsFundus is usually unremarkable, with some showing a faint intraretinal perifoveal ring. FAF showed typical trizonal pattern of involvement around the fovea. ERG showed a reduced scotopic as well as photopic response. OCT also showed a trizonal involvement with loss of ellipsoid zone and the cone outer segment tip (COST) line. Five out of six patients had good visual potential. Only one patient had poor visual prognosis which was correlated with greater retinal pigmentary changes at presentation.
ConclusionIndian patients tends to have a better visual prognosis as compared to other subcontinents provided appropriate and timely intervention is made. Multimodal imaging plays a pivotal role in making the diagnosis. We present the first largest series in south India.
Conflict of interestNo
Authors 1
Last namePATNAIK
Initials of first name(s)G
DepartmentUvea and Medical Retina
Authors 2
Last nameBiswas
Initials of first name(s)J
DepartmentUvea and Ocular Pathology