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TitleVitreous levels of interleukin-35 as a prognostic factor in B-cell vitreoretinal lymphoma
PurposeVitreoretinal lymphoma (VRL) is a rare disease of B-cell origin with poor prognosis. Regulatory cytokines promote tumor development by suppressing antitumor immunity in several cancer types. To identify the regulatory cytokines associated with poor prognosis in patients with B-cell VRL, we determined the regulatory cytokines profiles in the vitreous humor of patients with VRL.
MethodsThis retrospective study included 22 patients with VRL, 24 with noninfectious uveitis (NIU), and 20 with idiopathic epiretinal membrane (control). Undiluted vitreous fluid was obtained at the beginning of diagnostic vitrectomy at the Kyushu University Hospital, in Fukuoka, Japan, from January 2008 to April 2016. Vitreous concentrations of regulatory cytokines were assessed using a cytometric beads assay and association with clinical data was examined.
ResultsThe mean observation period was 48.7 months during the survey period from January 2008 to December 2019 in patients with VRL. Vitreous levels of interleukin (IL)-10 and IL-22 were increased in patients with VRL compared to those in the patients with NIU and the control. IL-35 and soluble IL-2 receptor α levels were significantly higher in patients with VRL and NIU than those in the control group. The five-year overall survival rates for the group with high intravitreal IL-35 was significantly poorer than those for the group with low intravitreal IL-35, who were diagnosed with VRL at the onset (P < 0.05).
ConclusionOur results suggest that high intravitreal IL-35 levels indicate poor prognosis for patients diagnosed with B-cell VRL at the onset.
Conflict of interestNo
Authors 1
Last nameTAKEDA
Initials of first name(s)AT
DepartmentOphthalmology, Kyushu University
Authors 2
Last nameKoh-Hei Sonoda
Initials of first name(s)KH.S
DepartmentOphthalmology, Kyushu University