View abstract

This abstract is assigned to sessions
Presentation preference Poster presentation
TitleAtypical granulomatous inflammation in patients with Behçet’s disease
PurposeTo describe cases of atypical granulomatous inflammation in patients with Behçet’s disease (BD).
MethodsWe retrospectively reviewed five cases of atypical granulomatous inflammation in patients with BD. Data were collected from patients' charts, including slit-lamp anterior segment photographs, fundus findings, general conditions, and treatments received.
ResultsWe present a case series of five patients who presented with granulomatous keratic precipitates (KPs) during the course of BD. All the patients were diagnosed as having Behçet’s disease on the basis of the findings of ocular inflammatory attacks, medical history, and extraocular manifestations. Atypical granulomatous inflammation was observed under treatment with biological agents in three cases (infliximab in 2 and adalimumab in 1) and colchicine in 2 cases. All the cases of granulomatous inflammation were unilateral. Three patients manifested mutton-fat KPs, and the remaining two patients had medium-sized KPs. Three cases were treated with local steroid eye drops, one case was treated with increased doses of methotrexate and subtenon triamcinolone acetonide injections, and another case was treated with infliximab administration scheduled for the same day. These granulomatous KPs disappeared rapidly in response to the treatment without antimicrobial agents.
ConclusionGranulomatous KPs could occur during the course of BD. These clinical characteristics must be considered to make an accurate diagnosis when atypical granulomatous inflammation is observed in patients with BD.
Conflict of interestNo
Authors 1
Initials of first name(s)C
DepartmentDepartment of Ophthalmology, Kindai University Faculty of Medicine
Authors 2
Last nameOHGURO
Initials of first name(s)N
DepartmentDepartment of Ophthalmology, Japan Community Health Care Organization Osaka Hospital